Biology of the apelin-APJ axis in vascular formation
نویسندگان
چکیده
منابع مشابه
Pancreatitis activates pancreatic apelin-APJ axis in mice.
Pancreatitis is classified into acute pancreatitis (AP) and chronic pancreatitis (CP). Apelin, a small regulatory peptide, is the endogenous ligand for the APJ receptor. Apelin and APJ are expressed in the pancreas. The aims of this study were to examine whether apelin influences the inflammatory and fibrosis responses to pancreatitis in mice and to identify mechanisms behind apelin's activitie...
متن کاملApelin-APJ signaling in retinal angiogenesis.
The G protein–coupled receptor (GPCR) APJ (X-msr, angiotensin receptor like 1b) was cloned in several laboratories by homology screening, with the goal of identifying new members of this class of cell surface receptor.1 This gene attracted attention because of its sequence similarity to the important angiotensin II type 1 receptor and its highly restricted pattern of expression in endothelial c...
متن کاملUpregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse.
AIMS To investigate apelin-APJ (angiotensin receptor-like 1) signalling in vascular remodelling, we have examined the pathophysiological response to carotid ligation in apelin knockout mice. METHODS AND RESULTS Apelin null animals compared with wild-type mice had significantly decreased neointimal lesion area (1.17 +/- 0.17 vs. 3.33 +/- 1.04 x 10(4) microm(2), P < 0.05) and intima/media ratio...
متن کاملThe Apelin-APJ System in the Evolution of Heart Failure
Heart failure is a chronic, progressive disease in which the overexpression of biologically active molecules and neurohomonal activation are the key factors of the evolution and natural history. The apelin-APJ system is a newly discovered molecular pathway and the RAAS counterbalance is its principal effect. The apelin is a potent inotrope, vasodilator and diuretic with crucial cardioprotective...
متن کاملApelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
OBJECTIVE The endothelial response elicited by the G-protein-coupled receptor pathway involving apelin and APJ predicts an overall vasoprotective effect. As a number of downstream endothelial targets of apelin/APJ signaling are also known to be targeted by statins (3-hydroxy-3-methyl-glutaryl [HMG]-CoA reductase inhibitors) as potential mediators of their known pleiotropic effects, we evaluated...
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ژورنال
عنوان ژورنال: Journal of Biochemistry
سال: 2012
ISSN: 0021-924X
DOI: 10.1093/jb/mvs071